MovDisordV3, Main, Exploration, bibRecord, 002A53

Subthalamic Nucleus Stimulation Restores Corticospinal Facilitation in Parkinson's Disease

Identifieur interne : 002A53 ( Main/Exploration ); précédent : 002A52; suivant : 002A54

Subthalamic Nucleus Stimulation Restores Corticospinal Facilitation in Parkinson's Disease

Auteurs : Monika Potter-Nerger [Allemagne] ; Tihomir V. Ilic [Allemagne, Serbie] ; Hartwiq R. Siebner [Allemagne] ; Günther Deuschl [Allemagne] ; Jens Volkmann [Allemagne]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:09-0038020

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Noyau sousthalamique, Facilitation, Cortex moteur, Réflexe H.

English descriptors

KwdEn :
- Facilitation, H-Reflex, Motor cortex, Nervous system diseases, Parkinson disease, Subthalamic nucleus.

Abstract

We have previously shown that in patients with Parkinson's disease (PD), high-frequency stimulation (HFS) of the subthalamic nucleus (STN) modifies spinal excitability via subcortical reticulospinal routes. To investigate whether STN-HFS also modifies spinal excitability via transcortical routes in PD, 10 patients with PD (9 men, I woman; 58.3 ± 8.3 years) were investigated in the medical OFF-state with or without STN-HFS. The H-reflex of the right soleus muscle was recorded during slight plantar flexion at 20% of maximum force. A conditioning transcranial stimulus was applied at 95% of active motor threshold to the contralateral primary motor leg area (Ml) 0-5 ms after eliciting the H-reflex. The same paradigm was applied to 8 healthy individuals (5 men, 3 women; 50.8 ± 3.0 years). Transcranial magnetic stimulation (TMS) facilitated the H-reflex amplitude in healthy controls. A facilitatory effect of the corticospinal input on the H-reflex was also found in patients with PD, but only with STN-HFS switched on. When STN-HFS was discontinued, the H-reflex was no longer facilitated by the TMS pulse. Accordingly, analysis of variance showed a main effect of stimulation (F = 11.15; P = 0.005), ISI (F = 6.1; P = 0.003), and an interaction between stimulation and group (PD vs. control) (F = 8.9; P = 0.01). STN-HFS restores the normal facilitatory drive of a transcranially evoked motor cortical response to the spinal motoneuron pool. In addition to subcortical routes, STN-DBS also alters spinal excitability via transcortical pathways.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">We have previously shown that in patients with Parkinson's disease (PD), high-frequency stimulation (HFS) of the subthalamic nucleus (STN) modifies spinal excitability via subcortical reticulospinal routes. To investigate whether STN-HFS also modifies spinal excitability via transcortical routes in PD, 10 patients with PD (9 men, I woman; 58.3 ± 8.3 years) were investigated in the medical OFF-state with or without STN-HFS. The H-reflex of the right soleus muscle was recorded during slight plantar flexion at 20% of maximum force. A conditioning transcranial stimulus was applied at 95% of active motor threshold to the contralateral primary motor leg area (Ml) 0-5 ms after eliciting the H-reflex. The same paradigm was applied to 8 healthy individuals (5 men, 3 women; 50.8 ± 3.0 years). Transcranial magnetic stimulation (TMS) facilitated the H-reflex amplitude in healthy controls. A facilitatory effect of the corticospinal input on the H-reflex was also found in patients with PD, but only with STN-HFS switched on. When STN-HFS was discontinued, the H-reflex was no longer facilitated by the TMS pulse. Accordingly, analysis of variance showed a main effect of stimulation (F = 11.15; P = 0.005), ISI (F = 6.1; P = 0.003), and an interaction between stimulation and group (PD vs. control) (F = 8.9; P = 0.01). STN-HFS restores the normal facilitatory drive of a transcranially evoked motor cortical response to the spinal motoneuron pool. In addition to subcortical routes, STN-DBS also alters spinal excitability via transcortical pathways.</div>
</front>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Subthalamic Nucleus Stimulation Restores Corticospinal Facilitation in Parkinson's Disease

Subthalamic Nucleus Stimulation Restores Corticospinal Facilitation in Parkinson's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri